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KMID : 0620919970290030161
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Experimental & Molecular Medicine
1997 Volume.29 No. 3 p.161 ~ p.164
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The apolipoprotein E genotyping using the PCR-RFLP was useful to linkage analysis of Alzheimer's disease families
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Moon Ju Oh/Moon Ju Oh
Eun Kee Chung/Young Min Shin/Kyung Ok Lee/Young Suk Park
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Abstract
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Apolipoprotein E (ape E) has three common alleles (ape ε 2, ε 3 and ε 4) that code for three major isoforms E2, E3 and E4. The isoforms differ from each other by a single amino acid substitutions at two positions and also differ in their binding affinity for the apo E receptors. Moreover, recently a strong association between the apo ε 4 allele and late-onset Alzheimer disease (AD) was demonstrated. In this study, were analyzed the apo E genotypes using the Hhal digestion of PCR amplified samples, and the apo ε 4 allele frequency from 70 AD patients and 106 normal population in Korea. The results suggested that the frequency of ε 4 allele among the AD patients (35.7%) was 3 times higher than that among the control population (13.7%). The data, which are in agreement with recent reports, suggests that the apo ε 4 allele is associated with AD in Korea.
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KEYWORD
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